Selective antagonists are advantageous over non-selective antagonists. This is because they have the minimum impact on the brain. On the other hand, the impact due to the non-selective antagonists in the brain is more harmful. Another major advantage of the selective antagonist over the nopironolactonen –selective antagonist is that in case of the non-selective antagonist is the lack of proper binding with the progesterone and androgen. This can cause the problems such as the drug inducted gynecomastia, pain the breast and the problem related to impotence. Another advantage is that the selective antagonist does not lead to the increase in the levels of hemoglobin (Donnelly‐Roberts et al 571-79). Therefore, selective antagonist can be given to the people who are suffering from diabetes. Therefore, it can be clearly said that the selective antagonists is much better in comparison to the non-selective advantageous. In case of non- elective antagonist, there is the decrease in the levels of plasma adiponectin levels. Other than this there is also a growth in HbA1C levels and control levels as well. Though, these are the things that are rarely observed in case of the non-selective antagonists.