代写论文:细胞研究

代写论文:细胞研究

溶血磷脂酸(LPA)是一种水溶性磷脂衍生物。该化合物的结构如图1所示。它被认为是在体内发现的甘油磷脂最简单的形式,它是一种众所周知的重要的细胞外信号分子。LPA与G蛋白偶联受体(也称为GPCR)发生反应,结果发现它可以改变许多不同的细胞反应。研究发现,在细胞增殖、细胞骨骼变化、钙离子流入和更多细胞活动(2,3)中,细胞生存操作过程的动态变化(2,3)。h·沃格特。w(4).自那以后,已在NCBI上发表了与LPA有关的7696篇全文期刊文章,其中有3875篇文章得到了NIH的资助。

代写论文:细胞研究
在当前时间,有多个LPA受体被发现并报告。最突出的是LPA1、LPA2和LPA3。它们分别被称为EDG2、EDG4和EDG7。最近鉴定的LPA受体包括LPA4,其中包括P2RY9, GPR23。除了这些化合物,LPA5和LPA6在系统中被发现。这些被称为GPR92和P2RY5, GPR87。这些研究表明LPA与它的受体结合,即异三聚体G蛋白,包括Gi/o, G12/13, Gq和Gs。他们被发现在许多细胞类型和模型系统中调解作用。它们在体内和体内也有相似之处。这是一个增益和损失函数的研究。这导致了生理和病理生理上的影响几乎每个器官系统和发展阶段的每一个有机体(5)。

代写论文:细胞研究

Lysophosphatidic acid (LPA) is a water soluble phospholipid derivative.The structure of the compound is shown in figure 1. It is the considered to be the simplest form of the glycerophospholipids that are discovered in vivo (1). The compound is a well-known important potent extracellular signaling molecule. LPA reacts with G protein-coupled receptors also known as GPCR, as a result of which it is found to alter many different cellular responses. It is found to change the dynamics of cell survival operational procedure in the cell proliferation, cytoskeletal changes, and calcium influx and in many more cellular activities (2, 3). The pharmacologically active LPA was initially isolated from brain extracts in 1961 by KIRSCHNER. H. and VOGT. W. (4). Since then, 7696 full-text journal articles related to LPA have already been published on NCBI and 3875 articles among them were supported by NIH grant.

代写论文:细胞研究
In the current times, there are multiple LPA receptors that are found to be discovered and reported. Th most prominent are the LPA1, LPA2, and LPA3. These are also known as EDG2, EDG4, and EDG7 respectively. The recently identified LPA receptors include LPA4 they include P2RY9, GPR23. Apart from these compounds the LPA5 and LPA6 are found in the systems. These are otherwise known as GPR92 and P2RY5, GPR87. These studies have revealed that LPA binds to its receptors, the heterotrimeric G proteins, and includes Gi/o, G12/13, Gq, and Gs. They are found to mediate effects in numerous cell types and model systems. These are also found to be similar in vitro and in vivo. There is the gain- and loss-of-function study. That has led to physiological and pathophysiological influences on almost every organ system and developmental stage of every organism (5).