Current technology does not yield positive prognosis for brain tumor. Brain tumors are malignant and aggressively attack the systemic process. Initial experimentation has proved that there is immense potential for nanomedicine. Nanotechnology can be defined as the method in which substances are essentially created for a number of biomedical usages. Particularly, a lot of emphasis has been given to the modes in which the drugs are delivered. Initial experimentation has shown the vast implications of nanomedicines. Primarily brain tumor affects selective properties of vascular endothelial cells and causes blood-brain-tumor barrier. Advent of nanotubes and development of extra membrane vesicles have proven to be novel pathways for drug delivery . Relatively Nano particles have more visible permeability into the brain. Nanoparticles have shown great potential for treating brain cancer. They have been instrumental in facilitating and providing treatment for cancer. Owing to these benefits there has been comprehensive research undertaken regarding cellular communication in the brain and transfer of materials and particles . In spite of these developments there has been certain factor that impedes the progress of these nanomedicines for treatment of cancer. Main issue is the delivery of nanomedicine into the brain. There are some inherent issues such as elimination of nanoparticles that prove to hinder the progress. Apart from this impeding factor what needs to be counted is the effect of the nanoparticles in vivo. It has been observed that there is a higher level of cellular toxicity that arises from this usage. There are a number of issues involved in procuring maximum efficiency of nanomedicines. These factors affect the targeting efficiency of nanoparticles and its distribution. It is essential to understand the molecular mechanism and cellular pathways to develop novel approaches for drug mediated delivery. Quantum dots, dendrimers, gold nanoparticles, magnetic nanoparticles, nanotubes, gold nanowires are some of the nanoparticles that have been currently investigated for its usage in drug delivery .
Primarily this thesis will focus on nanoparticles delivery into the cellular transport process a study and address the issues of drug delivery. For this purpose the current impediments for therapeutic nanomedicines, critical analysis of the different nanoparticles have been undertaken in this research. From this the discussions of the results and conclusions are drawn.